Protein Modification Reagents
Cayman Chemical ABBV-CLS-484hydrochlorIde 5mg
An inhibitor of PTP1N and PTP2N (IC50s = 2.5 and 1.8 nM, respectively); selective for PTP1N and PTP2N over PTP6N and PTP11N (IC50s = >10 µM for both) but does inhibit PTP9N (IC50 = 15 nM); potentiates IFN-γ-induced decreases in the proliferation of B16-F1 cancer cells at 1 µM; reduces tumor volume in combination with an anti-PD-L1 antibody in a B16-F1 melanoma murine model at 20 mg/kg per day; increases the number of CD8+ effector T cells, NK T cells, neutrophils, and monocytes expressing high levels of IFN-γ-induced genes, as well as increases M1 and decreases M2 macrophages, in the same mouse model a 20 mg/kg per day
Sigma Aldrich Fine Chemicals Biosciences Collagenase H from Clostri
Collagenase H is an enzyme mixture prepared from Clostridium histolyticum cultures by filtration ammonium sulfate precipitation dialysis and lyophilization.
Selleck Chemical LLC Avagacestat (BMS-708163) 50mg 1146699-66-2
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable ?-secretase inhibitor of A?40 and A?42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 25mg
Collagenase from Clostridium histolyticumPurity: | MW: 245.233 | 9001-12-1 | MFCD00130830 | 25mg
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 3ku
Collagenase from Clostridium histolyticumPurity: MW: | 9001-12-1 | MFCD00130830 | 3ku
ABclonal Technology RIN2 Rabbit pAb
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
STEMCELL Technologies Collagenase C, ACF, Size: 1 g
Collagenase C, Animal Component-Free (ACF) is obtained from cultures free of animal-derived materials. Collagenase is a protease consisting of a single polypeptide chain approximately 1,000 amino acid residues in length. Collagenase is capable of digesting native collagen fibrils commonly found in connective tissues and therefore is frequently used for tissue dissociation. Collagenase preparations contain the activity of several proteases including: collagenase, caseinase, clostripain, and trypsin (Kessler & Yaron). Collagenase C, ACF contains low levels of tryptic activity, similar to Collagenase Type IV, and is intended for use in applications where it is necessary to prevent the introduction of potential animal-derived pathogens.
Selleck Chemical LLC Bestatin 10mg 58970-76-6 Ubenimex
Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
ABclonal Technology RIN2 Rabbit pAb
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
ABclonal Technology PLA2G7 Rabbit pAb
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.
ABclonal Technology EP400 Rabbit pAb
Predicted to enable several functions, including ATP binding activity, ATP-dependent chromatin remodeler activity, and protein antigen binding activity. Involved in histone H2A acetylation and histone H4 acetylation. Part of NuA4 histone acetyltransferase complex and Swr1 complex.
ABclonal Technology ZC3H7A Rabbit pAb
Enables miRNA binding activity. Involved in production of miRNAs involved in gene silencing by miRNA. Predicted to be located in nucleus.
ABclonal Technology ANG Rabbit pAb
The protein encoded by this gene, known as RNase5 or angiogenin, is a member of the RNase A superfamily, though it has weak ribonucleolytic activity. It is a potent mediator of angiogenesis, binding to actin on endothelial cell surfaces to promote blood vessel formation. This protein also accumulates in the nucleolus to stimulate ribosomal transcription and, under stress, translocates to the cytosol to hydrolyze tRNAs, affecting protein synthesis. The mature protein, after cleavage of a signal peptide, contains a nuclear localization signal, a cell-binding motif, and a catalytic domain. It is neurotrophic, neuroprotective, and exhibits antimicrobial activity against bacteria and fungi, such as S. pneumoniae and C. albicans. This gene plays roles in cell growth and tumor progression, with mutations linked to amyotrophic lateral sclerosis (ALS). Alternative splicing produces multiple transcript variants encoding the same protein.